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Target population The primary targets of these new guidelines are patients with suspicious or newly diagnosed HCC. Accordingly, in the summer of 2021, the Korean Liver Cancer Association (KLCA, formerly KLCSG)- NCC Korea Practice Guideline Revision Committee (KPGRC) initiated the revision of the guidelines to develop a new recommendation plan that integrates the most upto-date research findings and expert opinions after the release of the 2018 guidelines. As many studies have been conducted, a substantial amount of knowledge have been accumulated on the diagnosis, staging, and treatment of HCC specific to Asia, with the study results showing different clinical behaviors from the West, especially in South Korea these new research findings have provided clinicians with various action plans and measures related to HCC.

Since then, an abundance of new research findings and therapies for HCC have been presented and published in South Korea and around the globe. Intent of revision The Korean Liver Cancer Study Group (KLCSG)-National Cancer Center (NCC) Korea practice guidelines for the management of hepatocellular carcinoma (HCC) were first announced in 2003 and have been revised three times first in 2009, second in 2014, and then in 2018. Keywords: Diagnosis Guidelines Hepatocellular carcinoma Management.These guidelines provide useful information and direction for all clinicians, trainees, and researchers in the diagnosis and treatment of HCC. A total of 49 experts in the fields of hepatology, oncology, surgery, radiology, and radiation oncology from the Korean Liver Cancer Association-National Cancer Center Korea Practice Guideline Revision Committee revised the 2018 Korean guidelines and developed new recommendations that integrate the most up-to-date research findings and expert opinions. The current practice guidelines will provide useful and sensible advice for the clinical management of patients with HCC.

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the fourth most common cancer among men in South Korea, where the prevalence of chronic hepatitis B infection is high in middle and old age.

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